Can registered nurses and nurse practitioners inject Botox and fillers in Colorado?

Yes, under physician delegation; supervision model varies—may be on-site or remote depending on board interpretation NP/PA may inject under physician collaboration; independent practice for injectables is not clearly permitted

Colorado · Moderate

Can RNs and Nurse Practitioners Inject Botox in Colorado?

Nurses do most of the injecting in this industry — but Colorado draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, under physician delegation; supervision model varies—may be on-site or remote depending on board interpretation

Nurse practitioners & physician assistants

NP/PA may inject under physician collaboration; independent practice for injectables is not clearly permitted

Supervision & the medical director

Required for facilities offering injectable procedures; physician oversight mandatory

The exam requirement

Required; in-person or telehealth allowed under certain conditions

What to verify in Colorado

Establish written physician delegation agreement and confirm medical director availability; clarify telehealth GFE policy with the Colorado Medical Board before implementing.

Primary source: Colorado Medical Board; Colorado Board of Nursing

General business information for Colorado medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the Colorado board (and your own counsel) before you act.

See the full Colorado regulation profile →

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