Can registered nurses and nurse practitioners inject Botox and fillers in Colorado?

Yes, under physician delegation; RN may inject with written standing orders or protocol from supervising physician NP/PA may inject under physician collaboration; independent practice for injectables not clearly permitted

Colorado · Moderate

Can RNs and Nurse Practitioners Inject Botox in Colorado?

Nurses do most of the injecting in this industry — but Colorado draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, under physician delegation; RN may inject with written standing orders or protocol from supervising physician

Nurse practitioners & physician assistants

NP/PA may inject under physician collaboration; independent practice for injectables not clearly permitted

Supervision & the medical director

Required; physician must oversee the medical spa and delegate procedures

The exam requirement

Required; in-person exam by physician or qualified provider before treatment

What to verify in Colorado

Retain a Colorado-licensed physician as medical director with clear written delegation protocols for all injectors, and verify current telehealth GFE rules with the Colorado Medical Board.

Primary source: Colorado Medical Board; Colorado Board of Nursing

General business information for Colorado medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the Colorado board (and your own counsel) before you act.

See the full Colorado regulation profile →

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