Can registered nurses and nurse practitioners inject Botox and fillers in Mississippi?

Yes, under direct physician delegation and supervision Requires physician collaboration and supervision

Mississippi · Strict

Can RNs and Nurse Practitioners Inject Botox in Mississippi?

Nurses do most of the injecting in this industry — but Mississippi draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, under direct physician delegation and supervision

Nurse practitioners & physician assistants

Requires physician collaboration and supervision

Supervision & the medical director

Required for RN/NP/PA injection activities

The exam requirement

Required, in-person preferred

What to verify in Mississippi

Verify physician medical director is licensed in Mississippi and maintains active malpractice coverage.

Primary source: Mississippi State Board of Medical Licensure

General business information for Mississippi medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the Mississippi board (and your own counsel) before you act.

See the full Mississippi regulation profile →

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