Can registered nurses and nurse practitioners inject Botox and fillers in Mississippi?

Yes, under physician delegation and supervision Requires physician collaboration/supervision

Mississippi · Moderate

Can RNs and Nurse Practitioners Inject Botox in Mississippi?

Nurses do most of the injecting in this industry — but Mississippi draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, under physician delegation and supervision

Nurse practitioners & physician assistants

Requires physician collaboration/supervision

Supervision & the medical director

Recommended but not explicitly mandated by state board

The exam requirement

Required; in-person preferred, telehealth varies by provider

What to verify in Mississippi

Establish clear physician supervision and delegation protocols in writing before hiring injectors.

Primary source: Mississippi State Board of Medical Licensure

General business information for Mississippi medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the Mississippi board (and your own counsel) before you act.

See the full Mississippi regulation profile →

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