Calcium Hydroxylapatite

Mineral scaffold that stimulates collagen and restores lost volume.

Also known as: Calcium hydroxyapatite, CaHA, Radiesse (brand name)

What it is

Calcium hydroxylapatite is a biocompatible mineral compound identical to the mineral phase of human bone and teeth. When suspended in a gel carrier, it forms a scaffold that provides immediate volume while triggering the body's own collagen production over months.

What it does

CaHA works in two phases: the gel carrier provides immediate lift and support, while the microspheres act as a biostimulatory scaffold that recruits fibroblasts and stimulates new collagen deposition. Over 12–24 months, the product is gradually replaced by the body's own collagen, creating a longer-lasting result than hyaluronic acid alone. It also has mild anti-inflammatory and bone-conductive properties.

The evidence

Strong clinical evidence supports its safety and efficacy for facial volume restoration and collagen stimulation, with multiple peer-reviewed studies showing sustained results at 12+ months. Moderate evidence exists for its use in non-facial areas and combination protocols.

Best for

Moderate to severe facial volume loss, nasolabial folds, marionette lines, and patients seeking longer-lasting results than HA fillers; ideal for those with realistic expectations about gradual collagen remodeling.

Pairs well with

Hyaluronic acid fillers (for fine lines), botulinum toxin (for dynamic wrinkles), microneedling (to enhance collagen response), and other biostimulators like poly-L-lactic acid.

Use cautiously with

Avoid combining with silicone or permanent fillers; use caution with active infections or severe immunosuppression; not recommended in areas prone to movement-related granulomas.

Cautions

Temporary swelling, bruising, and nodule formation possible; rare granulomas reported; not recommended during pregnancy or active skin infections; may cause mild discomfort on injection.