PRF (Platelet-Rich Fibrin)

Autologous fibrin matrix rich in platelets and growth factors.

Also known as: Platelet-Rich Fibrin, PRF, Leukocyte- and Platelet-Rich Fibrin (L-PRF), Advanced PRF (A-PRF)

What it is

PRF is a second-generation platelet concentrate derived from centrifuged autologous blood (your own blood). Unlike PRP, it forms a natural fibrin clot that slowly releases growth factors—including PDGF, VEGF, TGF-β, and FGF—over days to weeks, creating a bioscaffold that stimulates collagen remodeling and tissue regeneration.

What it does

PRF acts as both a delivery vehicle and structural matrix for growth factors. When injected into skin or used topically with microneedling, it triggers fibroblast activation, increases collagen synthesis, improves skin texture and firmness, and enhances skin hydration. The sustained-release mechanism makes it more effective than single-dose growth factor application, and it also promotes angiogenesis (new blood vessel formation) for improved skin quality.

The evidence

Moderate to strong evidence supports PRF for skin rejuvenation, collagen induction, and wound healing; most studies are in-vitro or small clinical series rather than large RCTs. Evidence is strongest for combination use with microneedling or as an adjunct to other biostimulators; emerging evidence supports its use for acne scarring and photoaging.

Best for

Aging, loss of firmness, dull texture, fine lines, mild-to-moderate scarring, and post-procedure healing; suits all skin types.

Pairs well with

Microneedling, radiofrequency, other biostimulators (like PLLA or BDDE), hyaluronic acid, and vitamin C serums.

Use cautiously with

Avoid combining with anticoagulants or NSAIDs immediately before/after (may reduce clotting); use cautiously with active infections or severe immunosuppression.

Cautions

Requires venipuncture and on-site preparation; results vary with blood quality and centrifugation protocol. Not suitable for patients on blood thinners or with clotting disorders; pregnancy and breastfeeding are relative contraindications pending more data. Mild bruising, swelling, and temporary redness are common.