Who can inject
MD, DO, NP, PA, RN under physician delegation
Registered nurses (RNs)
Yes, under physician delegation; no specific supervision requirement mandated
Nurse practitioners & physician assistants
NP/PA may practice and inject with physician collaboration; independent practice permitted in some settings
The exam that makes it legal
Required; in-person or telehealth allowed A valid order or good-faith exam by an authorized provider is what makes an injection lawful — not simply who holds the syringe.
Training expected
No state-mandated injector training beyond licensure.
What to verify in South Dakota
Establish a clear written agreement with a supervising physician and document all delegation and injection protocols to ensure compliance.
Primary source: South Dakota Medical Board; Board of Nursing
General business information for South Dakota medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the South Dakota board (and your own counsel) before you act.