Can registered nurses and nurse practitioners inject Botox and fillers in South Dakota?

Yes, under physician delegation; no specific supervision requirement mandated NP/PA may practice and inject with physician collaboration; independent practice permitted in some settings

South Dakota · Lenient

Can RNs and Nurse Practitioners Inject Botox in South Dakota?

Nurses do most of the injecting in this industry — but South Dakota draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, under physician delegation; no specific supervision requirement mandated

Nurse practitioners & physician assistants

NP/PA may practice and inject with physician collaboration; independent practice permitted in some settings

Supervision & the medical director

Not explicitly required by state statute for all facilities

The exam requirement

Required; in-person or telehealth allowed

What to verify in South Dakota

Establish a clear written agreement with a supervising physician and document all delegation and injection protocols to ensure compliance.

Primary source: South Dakota Medical Board; Board of Nursing

General business information for South Dakota medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the South Dakota board (and your own counsel) before you act.

See the full South Dakota regulation profile →

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