Licorice Root Extract

Soothing botanical that brightens and calms irritated skin.

Also known as: Glycyrrhiza glabra extract, licorice extract, glycyrrhizin, glabridin

What it is

Licorice root extract is derived from the Glycyrrhiza glabra plant and contains active compounds including glycyrrhizin and glabridin. It has been used in traditional medicine for centuries and is now a staple in modern skincare for its anti-inflammatory and skin-brightening properties.

What it does

Licorice root extract works through multiple mechanisms: glabridin inhibits tyrosinase, the enzyme responsible for melanin production, thereby reducing hyperpigmentation and dark spots. Glycyrrhizin provides potent anti-inflammatory effects that calm redness and irritation. It also has antioxidant properties that protect against environmental damage and support overall skin barrier health.

The evidence

Strong clinical evidence supports its use for hyperpigmentation and post-inflammatory erythema; multiple peer-reviewed studies demonstrate efficacy in reducing melanin production and calming irritated skin. Evidence is particularly robust for glabridin's tyrosinase-inhibiting activity.

Best for

Hyperpigmentation, melasma, post-inflammatory erythema, sensitive or reactive skin, and those seeking gentle brightening without irritation.

Pairs well with

Niacinamide, vitamin C, kojic acid, azelaic acid, and hydrating humectants like glycerin; works synergistically with other brightening agents.

Use cautiously with

No major conflicts; however, use cautiously with other strong depigmenting agents at high concentrations to avoid over-treatment.

Cautions

Generally well-tolerated; rare cases of contact dermatitis reported in sensitive individuals. Systemic absorption of glycyrrhizin is minimal in topical formulations, but those with hypertension or on corticosteroids should consult a physician before oral supplementation.