Can registered nurses and nurse practitioners inject Botox and fillers in South Carolina?

Yes, under physician delegation and supervision NP/PA may inject under physician collaboration; independent practice limited

South Carolina · Moderate

Can RNs and Nurse Practitioners Inject Botox in South Carolina?

Nurses do most of the injecting in this industry — but South Carolina draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, under physician delegation and supervision

Nurse practitioners & physician assistants

NP/PA may inject under physician collaboration; independent practice limited

Supervision & the medical director

Required for RN/LPN injectors; physician oversight mandatory

The exam requirement

Required; in-person exam before treatment

What to verify in South Carolina

Establish a clear physician medical director agreement and ensure all RN/LPN injectors have documented delegation protocols.

Primary source: South Carolina Medical Board

General business information for South Carolina medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the South Carolina board (and your own counsel) before you act.

See the full South Carolina regulation profile →

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