Beta-Glucan

Polysaccharide that hydrates and strengthens skin barrier function.

Also known as: Beta-1,3/1,6-glucan, yeast beta-glucan, fungal polysaccharide, same name.

What it is

Beta-glucan is a naturally occurring polysaccharide derived primarily from yeast cell walls (Saccharomyces cerevisiae) or oat bran. It's a chain of glucose molecules linked in a specific pattern that gives it unique biological activity in skin.

What it does

Beta-glucan acts as a humectant, drawing water into the stratum corneum to improve hydration and skin plumpness. It also activates skin immune receptors (Dectin-1), triggering production of cytokines and growth factors that strengthen barrier function, reduce inflammation, and support wound healing and collagen synthesis.

The evidence

Strong clinical evidence supports hydration and barrier-strengthening effects; multiple peer-reviewed studies confirm improved skin moisture, elasticity, and reduced transepidermal water loss. Evidence for immune activation and anti-inflammatory benefit is moderate to strong in both in vitro and in vivo models.

Best for

Dehydrated, sensitive, compromised, or inflamed skin; barrier repair; post-procedure soothing.

Pairs well with

Hyaluronic acid, ceramides, niacinamide, centella asiatica, peptides, and other barrier-supporting actives.

Use cautiously with

No major conflicts; generally well-tolerated alongside most ingredients. May be redundant if combined with multiple other humectants at high concentration.

Cautions

Well-tolerated and non-irritating; suitable for pregnancy and sensitive skin. No known sun-sensitivity or prescription interactions.